Headed by Dr Eric Rubinstein, DR Inserm

Goals: To understand the function role of tetraspanins microdomain, their physiological role and their involvement in diseases, in cell differentiation, cancer progression, cellular fusion and stem cell trafficking

Thematics:

1.Regulation of Notch signaling by TspanC8 tetraspanin  
2.Deciphering the mechanisms of muscle cell fusion via the study of tetraspanins and physiopathological implications
3.Targeting Tspan8 in colon cancer and melanoma