• Myeloproliferative disorders and Myelodysplastic syndrome

 Chronic myeloid leukemia (CML), MPD Ph1-, MDS, acute leukemia. (Team 1 and Atip Avenir)
CML and MDS murine models
Circadian genes in BCR-ABL-associated leukemogenesis and quiescence
Hematopoietic Stem Cells, clonal analysis and hierarchy
Novel targets in CML and MDS stem cells
Disease modeling from patient-specific iPSC (Team 1 and Esteam)
Immuno-oncology therapy (Team 1 and Esteam)
  • Solid Tumors

 Hereditary cancers:
Initiating event in tumorogenesis : IPSC Models with BRCA, cMET, RET mutations (Team 1 and Esteam)

Somatic cancer:

Beast cancer : Epithelial Mesenchymal Transition and stemness induction (Team 1)
Hepatocellular carcinoma:  Chronobiology and chronotherapy (Team 3)
Colon cancer: Tetraspanins  and signaling pathways (Team 2)
  • Regenerative medicine and cell therapy

Preclinical models in large pig and NH Primate (ESteam )
Hematopoiesis and HSC generation from hESC and hiPSC (Team 1 and ESteam)
Immune therapy and cancer vaccine (Team 1 and ESteam)
MSC and ischemic lesions (Team 1 and3)
Optimization post-surgery liver function- organ perfusion  (Team 3 and 1)